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Attenuation of Biopterin Synthesis Prevents Escherichia coli K1 Invasion of Brain Endothelial Cells and the Development of Meningitis in Newborn Mice

Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular endothelial cells (HBMECs) induces the expression of guanosine triphosphate cyclohydrolase (GCH1), the...

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Detaylı Bibliyografya
Asıl Yazarlar: Shanmuganathan, Muthusamy V., Krishnan, Subramanian, Fu, Xiaowei, Prasadarao, Nemani V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523800/
https://ncbi.nlm.nih.gov/pubmed/23100563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis656
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