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Attenuation of Biopterin Synthesis Prevents Escherichia coli K1 Invasion of Brain Endothelial Cells and the Development of Meningitis in Newborn Mice
Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular endothelial cells (HBMECs) induces the expression of guanosine triphosphate cyclohydrolase (GCH1), the...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523800/ https://ncbi.nlm.nih.gov/pubmed/23100563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis656 |
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