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Tracking transmitter-gated P2X cation channel activation in vitro and in vivo

We present a noninvasive approach to track activation of ATP-gated P2X receptors and potentially other transmitter-gated cation channels that show calcium fluxes. We genetically engineered rat P2X receptors to carry calcium sensors near the channel pore and tested this as a reporter for P2X(2) recep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Richler, Esther, Chaumont, Severine, Shigetomi, Eiji, Sagasti, Alvaro, Khakh, Baljit S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523716/
https://ncbi.nlm.nih.gov/pubmed/18084300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth1144
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