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Overexpression of BMP3 in the Developing Skeleton Alters Endochondral Bone Formation Resulting in Spontaneous Rib Fractures

Bone morphogenetic protein-3 (BMP) has been identified as a negative regulator in the skeleton as mice lacking BMP3 have increased bone mass. To further understand how BMP3 mediates bone formation, we created transgenic mice overexpressing BMP3 using the type I collagen promoter. BMP3 transgenic mic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gamer, Laura W., Cox, Karen, Carlo, Joelle M., Rosen, Vicki
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523674/
https://ncbi.nlm.nih.gov/pubmed/19653325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.22048
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