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Acidosis and correction of acidosis does not affect rFVIIa function in swine

Background: Hemorrhagic shock and trauma are associated with acidosis and altered coagulation. A fall in pH has been reported to attenuate the activity of recombinant activated Factor VII (rFVIIa) in vitro. However, it is not known if acidosis induced by hemorrhagic shock or infusion of HCl attenuat...

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Detalhes bibliográficos
Main Authors: Darlington, Daniel N, Kheirabadi, Bijan S, Scherer, Michael R, Martini, Wenjun Z, Cap, Andrew P, Dubick, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523398/
https://ncbi.nlm.nih.gov/pubmed/23272296
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