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Ratanhiaphenol III from Ratanhiae Radix is a PTP1B Inhibitor

The inhibition of protein tyrosine phosphatase 1B (PTP1B) is considered a valid strategy to combat insulin resistance and type II diabetes. We show here that a dichloromethane extract of Ratanhiae radix (RR_ex) dose-dependently inhibits human recombinant PTP1B in vitro and enhances insulin-stimulate...

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Détails bibliographiques
Auteurs principaux: Heiss, Elke H., Baumgartner, Lisa, Schwaiger, Stefan, Heredia, Raul Jimenez, Atanasov, Atanas G., Rollinger, Judith M., Stuppner, Hermann, Dirsch, Verena M.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523387/
https://ncbi.nlm.nih.gov/pubmed/22307937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0031-1298242
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