Loss of the p53/p63 Target PERP is an Early Event in Oral Carcinogenesis and Correlates with Higher Rate of Local Relapse

BACKGROUND: PERP is a p53/p63 regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression. STUDY DESIGN: We evaluated PERP expression in different grades of oral dysplasia (34 cases) and at different stages of invasive squamous cell carcinoma (...

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Detalhes bibliográficos
Main Authors: Kong, Christina S., Cao, Hongbin, Kwok, Shirley, Nguyen, Catherine M., Jordan, Richard C., Beaudry, Veronica G., Attardi, Laura D., Le, Quynh-Thu
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523282/
https://ncbi.nlm.nih.gov/pubmed/23217540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oooo.2012.10.017
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