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Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans
The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7. 3 μM.
Bewaard in:
| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523195/ https://ncbi.nlm.nih.gov/pubmed/21715177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.05.041 |
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