PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

BACKGROUND: This study investigated variation in NR1I2 and NR1I3 and its effect on plasma efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led research on identifying causative variants in drug metabolising enzyme (DME) genes, with little focus on the nuclear rece...

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Bibliographic Details
Main Authors: Swart, Marelize, Whitehorn, Heather, Ren, Yuan, Smith, Peter, Ramesar, Rajkumar S, Dandara, Collet
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523080/
https://ncbi.nlm.nih.gov/pubmed/23173844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-13-112
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