Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging

AIMS: We sought to describe quantitatively the distribution of rectally administered gels and seminal fluid surrogates using novel concentration–distance parameters that could be repeated over time. These methods are needed to develop rationally rectal microbicides to target and prevent HIV infectio...

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Detalhes bibliográficos
Main Authors: Cao, Ying J, Caffo, Brian S, Fuchs, Edward J, Lee, Linda A, Du, Yong, Li, Liye, Bakshi, Rahul P, Macura, Katarzyna, Khan, Wasif A, Wahl, Richard L, Grohskopf, Lisa A, Hendrix, Craig W
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Methods in Clinical Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522815/
https://ncbi.nlm.nih.gov/pubmed/22404308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04267.x
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