Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

AIMS: This study aimed to investigate the effect of metamizole on bupropion hydroxylation related to different CYP2B6 genotype groups in healthy volunteers. METHODS: Sixteen healthy male volunteers (6 CYP2B6*1/*1, 6 CYP2B6*1/*6 and 4 CYP2B6*6/*6) received orally administered bupropion alone and duri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Qin, Wen-Jie, Zhang, Wei, Liu, Zhao-Qian, Chen, Xiao-Ping, Tan, Zhi-Rong, Hu, Dong-Li, Wang, Dan, Fan, Lan, Zhou, Hong-Hao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2012
Schlagworte:
Drug Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522813/
https://ncbi.nlm.nih.gov/pubmed/22519658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04304.x
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