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Molecular Modeling of the Reaction Pathway and Hydride Transfer Reactions of HMG-CoA Reductase
HMG-CoA reductase catalyzes the four electron reduction of HMG-CoA to mevalonate and is an enzyme of considerable biomedical relevance due to the impact of its statin inhibitors on public health. Although the reaction has been studied extensively using x-ray crystallography, there are surprisingly n...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522576/ https://ncbi.nlm.nih.gov/pubmed/22971202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3008593 |
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