Cytochrome P450-catalysed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

Thaxtomin phytotoxins produced by plant-pathogenic Streptomyces species contain a nitro group that is essential for phytotoxicity. The N,N’-dimethyldiketopiperazine core of thaxtomins is assembled from L-phenylalanine and L-4-nitrotryptophan by a nonribosomal peptide synthetase and nitric oxide synt...

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Bibliographische Detailangaben
Hauptverfasser: Barry, Sarah M., Kers, Johan A., Johnson, Evan G., Song, Lijiang, Aston, Philip R., Patel, Bhumit, Krasnoff, Stuart B., Crane, Brian R., Gibson, Donna M., Loria, Rosemary, Challis, Gregory L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522571/
https://ncbi.nlm.nih.gov/pubmed/22941045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1048
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