Crystal Structure of a Voltage-gated K(+) Channel Pore Module in a Closed State in Lipid Membranes

Voltage-gated K(+) channels underlie the electrical excitability of cells. Each subunit of the functional tetramer consists of the tandem fusion of two modules, an N-terminal voltage-sensor and a C-terminal pore. To investigate how sensor coupling to the pore generates voltage-dependent channel open...

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Main Authors: Santos, Jose S., Asmar-Rovira, Guillermo A., Han, Gye Won, Liu, Wei, Syeda, Ruhma, Cherezov, Vadim, Baker, Kent A., Stevens, Raymond C., Montal, Mauricio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522301/
https://ncbi.nlm.nih.gov/pubmed/23095758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415091
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