Uncoupling of Nucleotide Hydrolysis and Polymerization in the ParA Protein Superfamily Disrupts DNA Segregation Dynamics

DNA segregation in bacteria is mediated most frequently by proteins of the ParA superfamily that transport DNA molecules attached via the segrosome nucleoprotein complex. Segregation is governed by a cycle of ATP-induced polymerization and subsequent depolymerization of the ParA factor. Here, we est...

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Detalhes bibliográficos
Main Authors: Dobruk-Serkowska, Aneta, Caccamo, Marisa, Rodríguez-Castañeda, Fernando, Wu, Meiyi, Bryce, Kerstyn, Ng, Irene, Schumacher, Maria A., Barillà, Daniela, Hayes, Finbarr
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522256/
https://ncbi.nlm.nih.gov/pubmed/23093445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410324
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