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Restoration of Topoisomerase 2 Function by Complementation of Defective Monomers in Drosophila
Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3522162/ https://ncbi.nlm.nih.gov/pubmed/22923380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.144006 |
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