Comparative Nephrotoxicity of Gentamicin and Tobramycin in Rats

A rat model was utilized to compare the nephrotoxic potential of gentamicin and tobramycin. Gentamicin, 40 mg/kg per day, predictably produced renal failure and morphological evidence of proximal tubular necrosis over 14 days of treatment. An identical dosage of tobramycin was associated with only m...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Gilbert, D. N., Plamp, C., Starr, P., Bennett, W. M., Houghton, D. C., Porter, G.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1978
Sujets:	Pharmacology and Therapeutics
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352181/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/626489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.13.1.34
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