Block of Death-Receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and Is a Determinant of Virulence in Immunodeficient Hosts

The inhibition of death-receptor apoptosis is a conserved viral function. The murine cytomegalovirus (MCMV) gene M36 is a sequence and functional homologue of the human cytomegalovirus gene UL36, and it encodes an inhibitor of apoptosis that binds to caspase-8, blocks downstream signaling and thus c...

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Detalhes bibliográficos
Main Authors: Ebermann, Linda, Ruzsics, Zsolt, Guzmán, Carlos A., van Rooijen, Nico, Casalegno-Garduño, Rosaely, Koszinowski, Ulrich, Čičin-Šain, Luka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521658/
https://ncbi.nlm.nih.gov/pubmed/23271968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003062
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