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ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis

The present study aims to determine the effect of AMPK on etoposide-induced apoptosis of cancer cells. Our results revealed that etoposide induced AMPK activation in prostate C4-2 cancer cells, an event that was attenuated by ATM siRNA. In A549 cells that lack LKB1, AMPK was unable to be activated b...

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Autors principals: Luo, Lingyu, Huang, Wei, Tao, Rong, Hu, Ningyan, Xiao, Zhi-Xiong, Luo, Zhijun
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521637/
https://ncbi.nlm.nih.gov/pubmed/22960274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.08.034
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