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ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis
The present study aims to determine the effect of AMPK on etoposide-induced apoptosis of cancer cells. Our results revealed that etoposide induced AMPK activation in prostate C4-2 cancer cells, an event that was attenuated by ATM siRNA. In A549 cells that lack LKB1, AMPK was unable to be activated b...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3521637/ https://ncbi.nlm.nih.gov/pubmed/22960274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.08.034 |
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