Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation

Escherichia coli DksA is a transcription factor that binds to RNA polymerase (RNAP) without binding to DNA, destabilizing RNAP–promoter interactions, sensitizing RNAP to the global regulator ppGpp, and regulating transcription of several hundred target genes, including those encoding rRNA. Previousl...

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Detalhes bibliográficos
Main Authors: Lennon, Christopher W., Ross, Wilma, Martin-Tumasz, Stephen, Toulokhonov, Innokenti, Vrentas, Catherine E., Rutherford, Steven T., Lee, Jeong-Hyun, Butcher, Samuel E., Gourse, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521624/
https://ncbi.nlm.nih.gov/pubmed/23207918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.204693.112
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