Receptor Tyrosine Kinase ErbB2 Translocates into Mitochondria and Regulates Cellular Metabolism

It is well known that ErbB2, a receptor tyrosine kinase, localizes on the plasma membrane. Here we describe a novel observation that ErbB2 also localizes in mitochondria of cancer cells and patient samples. We found that ErbB2 translocates into mitochondria through the association with mtHSP70. Addi...

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Main Authors: Ding, Yan, Liu, Zixing, Desai, Shruti, Zhao, Yuhua, Liu, Hao, Pannell, Lewis K, Yi, Hong, Wright, Elizabeth R, Owen, Laurie B, Dean-Colomb, Windy, Fodstad, Oystein, Lu, Jianrong, LeDoux, Susan P, Wilson, Glenn L, Tan, Ming
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521558/
https://ncbi.nlm.nih.gov/pubmed/23232401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2236
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