Novel Actinomycins Formed by Biosynthetic Incorporation of cis- and trans-4-Methylproline

Streptomyces parvulus (Streptomyces parvullus) normally produces actinomycin D; in the presence of cis-4-methylproline, this species synthesizes two additional actinomycins, designated K(1c) and K(2c), in which one and two proline sites, respectively, are occupied by cis-4-methylproline. Analogously...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Katz, E., Williams, W. K., Mason, K. T., Mauger, A. B.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1977
Sujets:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352128/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/69418/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.11.6.1056
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