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Using the time-to-event continual reassessment method in the presence of partial orders
The time-to-event continual reassessment method (TITE-CRM) was proposed to handle the problem of long trial duration in Phase 1 trials as a result of late-onset toxicities. Here, we implement the TITE-CRM in dose–finding trials of combinations of agents. When studying multiple agents, monotonicity o...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3521068/ https://ncbi.nlm.nih.gov/pubmed/22806898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5491 |
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