Negative epistasis between the malaria-protective effects of α(+)-thalassemia and the sickle cell trait

The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria(1). In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural variant hemoglobin S and α(+)-thalassemia, a condition characterized by reduc...

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Hauptverfasser: Williams, Thomas N, Mwangi, Tabitha W, Wambua, Sammy, Peto, Timothy E A, Weatherall, David J, Gupta, Sunetra, Recker, Mario, Penman, Bridget S, Uyoga, Sophie, Macharia, Alex, Mwacharo, Jedidah K, Snow, Robert W, Marsh, Kevin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521056/
https://ncbi.nlm.nih.gov/pubmed/16227994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1660
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