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Negative epistasis between the malaria-protective effects of α(+)-thalassemia and the sickle cell trait
The hemoglobinopathies, disorders of hemoglobin structure and production, protect against death from malaria(1). In sub-Saharan Africa, two such conditions occur at particularly high frequencies: presence of the structural variant hemoglobin S and α(+)-thalassemia, a condition characterized by reduc...
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| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3521056/ https://ncbi.nlm.nih.gov/pubmed/16227994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1660 |
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