Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Testicular Germ Cell Tumors (TGCT) and patient-derived cell lines are extremely sensitive to cisplatin and other interstrand cross-link (ICL) inducing agents. Nevertheless, a subset of TGCTs are either innately resistant or acquire resistance to cisplatin during treatment. Understanding the mechanis...

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Main Authors: Cavallo, Francesca, Graziani, Grazia, Antinozzi, Cristina, Feldman, Darren R., Houldsworth, Jane, Bosl, George J., Chaganti, Raju S. K., Moynahan, Mary Ellen, Jasin, Maria, Barchi, Marco
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520950/
https://ncbi.nlm.nih.gov/pubmed/23251575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051563
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