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A Novel SERPINA1 Mutation Causing Serum Alpha(1)-Antitrypsin Deficiency

Mutations in the SERPINA1 gene can cause deficiency in the circulating serine protease inhibitor α(1)-Antitrypsin (α(1)AT). α(1)AT deficiency is the major contributor to pulmonary emphysema and liver disease in persons of European ancestry, with a prevalence of 1 in 2500 in the USA. We present the d...

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Autors principals: Saunders, Darren N., Tindall, Elizabeth A., Shearer, Robert F., Roberson, Jacquelyn, Decker, Amy, Wilson, Jean Amos, Hayes, Vanessa M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520848/
https://ncbi.nlm.nih.gov/pubmed/23251618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051762
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