Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate

Mutations in the ATP-binding cassette transporter A1 (ABCA1) are a major cause of decreased HDL cholesterol (HDL-C), which infers an increased risk of cardiovascular disease (CVD). Many ABCA1 mutants show impaired localization to the plasma membrane. The aim of this study was to investigate whether...

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Autors principals: Sorrenson, Brie, Suetani, Rachel J., Williams, Michael J. A., Bickley, Vivienne M., George, Peter M., Jones, Gregory T., McCormick, Sally P. A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2013
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520540/
https://ncbi.nlm.nih.gov/pubmed/23087442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M027193
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