Inflammation, Apoptosis, and Necrosis Induced by Neoadjuvant Fas Ligand Gene Therapy Improves Survival of Dogs With Spontaneous Bone Cancer

Fas ligand (FasL) gene therapy for cancer has shown promise in rodents; however, its efficacy in higher mammals remains unknown. Here, we used intratumoral FasL gene therapy delivered in an adenovirus vector (Ad-FasL) as neoadjuvant to standard of care in 56 dogs with osteosarcoma. Tumors from treat...

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Detalhes bibliográficos
Main Authors: Modiano, Jaime F, Bellgrau, Donald, Cutter, Gary R, Lana, Susan E, Ehrhart, Nicole P, Ehrhart, EJ, Wilke, Vicki L, Charles, J Brad, Munson, Sibyl, Scott, Milcah C, Pozniak, John, Carlson, Cathy S, Schaack, Jerome, Duke, Richard C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519983/
https://ncbi.nlm.nih.gov/pubmed/22850679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.149
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