A Tumor-stroma Targeted Oncolytic Adenovirus Replicated in Human Ovary Cancer Samples and Inhibited Growth of Disseminated Solid Tumors in Mice

Targeting the tumor stroma in addition to the malignant cell compartment is of paramount importance to achieve complete tumor regression. In this work, we modified a previously designed tumor stroma-targeted conditionally replicative adenovirus (CRAd) based on the SPARC promoter by introducing a mut...

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Detalhes bibliográficos
Main Authors: Lopez, M Veronica, Rivera, Angel A, Viale, Diego L, Benedetti, Lorena, Cuneo, Nicasio, Kimball, Kristopher J, Wang, Minghui, Douglas, Joanne T, Zhu, Zeng B, Bravo, Alicia I, Gidekel, Manuel, Alvarez, Ronald D, Curiel, David T, Podhajcer, Osvaldo L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519982/
https://ncbi.nlm.nih.gov/pubmed/22948673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.147
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