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What Can We Learn from the Evolution of Protein-Ligand Interactions to Aid the Design of New Therapeutics?
Efforts to increase affinity in the design of new therapeutic molecules have tended to lead to greater lipophilicity, a factor that is generally agreed to be contributing to the low success rate of new drug candidates. Our aim is to provide a structural perspective to the study of lipophilic efficie...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3519888/ https://ncbi.nlm.nih.gov/pubmed/23240060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051742 |
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