Smac Mimetic SM-164 Potentiates APO2L/TRAIL- and Doxorubicin-Mediated Anticancer Activity in Human Hepatocellular Carcinoma Cells

BACKGROUND: The members of inhibitor of apoptosis proteins (IAPs) family are key negative regulators of apoptosis. Overexpression of IAPs are found in hepatocellular carcinoma (HCC), and can contribute to chemotherapy resistance and recurrence of HCC. Small-molecule Second mitochondria-derived activ...

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Hlavní autoři: Zhang, Shuijun, Li, Gongquan, Zhao, Yongfu, Liu, Guangzhi, Wang, Yu, Ma, Xiuxian, Li, Dexu, Wu, Yang, Lu, Jianfeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519882/
https://ncbi.nlm.nih.gov/pubmed/23240027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051461
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