Signal Transduction Pathways (MAPKs, NF-κB, and C/EBP) Regulating COX-2 Expression in Nasal Fibroblasts from Asthma Patients with Aspirin Intolerance

BACKGROUND: Recent studies have revealed that cyclooxygenase-2 (COX-2) expression is down-regulated in aspirin-induced asthma (AIA). Various signal pathways (MAPKs, NF-κB and C/EBP) are involved in COX-2 regulation. OBJECTIVE: To investigate the regulation of COX-2 expression through MAP-kinase path...

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Main Authors: Garcia-Garcia, Francesc Josep, Mullol, Joaquim, Perez-Gonzalez, Maria, Pujols, Laura, Alobid, Isam, Roca-Ferrer, Jordi, Picado, Cesar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519844/
https://ncbi.nlm.nih.gov/pubmed/23240010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051281
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