Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals

ADA is an enzyme implicated in purine metabolism, and is critical to ensure normal immune function. Its congenital deficit leads to severe combined immunodeficiency (SCID). ADA binding to adenosine receptors on dendritic cell surface enables T-cell costimulation through CD26 crosslinking, which enha...

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Bibliographische Detailangaben
Hauptverfasser: Casanova, Víctor, Naval-Macabuhay, Isaac, Massanella, Marta, Rodríguez-García, Marta, Blanco, Julià, Gatell, José M., García, Felipe, Gallart, Teresa, Lluis, Carme, Mallol, Josefa, Franco, Rafael, Climent, Núria, McCormick, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519778/
https://ncbi.nlm.nih.gov/pubmed/23240012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051287
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