Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals

ADA is an enzyme implicated in purine metabolism, and is critical to ensure normal immune function. Its congenital deficit leads to severe combined immunodeficiency (SCID). ADA binding to adenosine receptors on dendritic cell surface enables T-cell costimulation through CD26 crosslinking, which enha...

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Main Authors: Casanova, Víctor, Naval-Macabuhay, Isaac, Massanella, Marta, Rodríguez-García, Marta, Blanco, Julià, Gatell, José M., García, Felipe, Gallart, Teresa, Lluis, Carme, Mallol, Josefa, Franco, Rafael, Climent, Núria, McCormick, Peter J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519778/
https://ncbi.nlm.nih.gov/pubmed/23240012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051287
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