Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice

BACKGROUND: Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. METHODS: Mice w...

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Detalhes bibliográficos
Main Authors: Botelho, Fernando M, Nikota, Jake K, Bauer, Carla MT, Morissette, Mathieu C, Iwakura, Yoichiro, Kolbeck, Roland, Finch, Donna, Humbles, Alison A, Stämpfli, Martin R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519608/
https://ncbi.nlm.nih.gov/pubmed/22992200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-13-81
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