IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

BACKGROUND: Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood. METHODO...

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Main Authors: Botelho, Fernando M., Bauer, Carla M. T., Finch, Donna, Nikota, Jake K., Zavitz, Caleb C. J., Kelly, Ashling, Lambert, Kristen N., Piper, Sian, Foster, Martyn L., Goldring, James J. P., Wedzicha, Jadwiga A., Bassett, Jennifer, Bramson, Jonathan, Iwakura, Yoichiro, Sleeman, Matthew, Kolbeck, Roland, Coyle, Anthony J., Humbles, Alison A., Stämpfli, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232226/
https://ncbi.nlm.nih.gov/pubmed/22163019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028457
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