IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

BACKGROUND: Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD), a major cause of morbidity and mortality worldwide. Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood. METHODO...

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Main Authors: Botelho, Fernando M., Bauer, Carla M. T., Finch, Donna, Nikota, Jake K., Zavitz, Caleb C. J., Kelly, Ashling, Lambert, Kristen N., Piper, Sian, Foster, Martyn L., Goldring, James J. P., Wedzicha, Jadwiga A., Bassett, Jennifer, Bramson, Jonathan, Iwakura, Yoichiro, Sleeman, Matthew, Kolbeck, Roland, Coyle, Anthony J., Humbles, Alison A., Stämpfli, Martin R.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232226/
https://ncbi.nlm.nih.gov/pubmed/22163019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028457
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