Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

BACKGROUND: Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to investigate whether intrathecal pretreatment with amitriptyline combined with p...

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Detalhes bibliográficos
Main Authors: Cheng, Kuang-I, Wang, Hung-Chen, Chang, Lin-Li, Wang, Fu-Yen, Lai, Chung-Sheng, Chou, Chao-Wen, Tsai, Hung-Pei, Kwan, Aij-Lie
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519508/
https://ncbi.nlm.nih.gov/pubmed/22720761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2377-12-44
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