CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary vascular dementia caused by mutations in NOTCH3 gene. Pathology is manifested in small- and middle-sized arteries throughout the body, though primarily in cerebral white...

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Bibliografiske detaljer
Main Authors: Tikka, Saara, Peng Ng, Yan, Di Maio, Giuseppe, Mykkänen, Kati, Siitonen, Maija, Lepikhova, Tatiana, Pöyhönen, Minna, Viitanen, Matti, Virtanen, Ismo, Kalimo, Hannu, Baumann, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519411/
https://ncbi.nlm.nih.gov/pubmed/22948298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.123
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