Stable Synthetic Bacteriochlorins for Photodynamic Therapy: Role of Dicyano Peripheral Groups, Central Metal Substitution (2H, Zn, Pd), and Cremophor EL Delivery

A series of four stable synthetic bacteriochlorins was tested in vitro in HeLa cells for their potential in photodynamic therapy (PDT). The parent bacteriochlorin (BC), dicyano derivative (NC)(2)BC and corresponding zinc chelate (NC)(2)BC–Zn and palladium chelate (NC)(2)BC–Pd were studied. Direct di...

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Main Authors: Huang, Ying-Ying, Balasubramanian, Thiagarajan, Yang, Eunkyung, Luo, Dianzhong, Diers, James R., Bocian, David F., Lindsey, Jonathan S., Holten, Dewey, Hamblin, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519240/
https://ncbi.nlm.nih.gov/pubmed/23065820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200351
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