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Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysms

RATIONALE: Abdominal aortic aneurysms (AAAs) exhibit marked sexual dimorphism with higher prevalences in men. Similarly, AAAs induced by angiotensin II (AngII) infusion into mice exhibit a higher prevalence in males. Testosterone promotes AAA pathology in adult male mice through regulation of angiot...

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Bibliografski detalji
Glavni autori: Zhang, Xuan, Thatcher, Sean E., Rateri, Debra L., Bruemmer, Dennis, Charnigo, Richard, Daugherty, Alan, Cassis, Lisa A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518797/
https://ncbi.nlm.nih.gov/pubmed/22539767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.253880
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