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Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction

Hearing and balance use hair cells in the inner ear to transform mechanical stimuli into electrical signals(1). Mechanical force from sound waves or head movements is conveyed to hair-cell transduction channels by tip links(2,3), fine filaments formed by two atypical cadherins: protocadherin-15 and...

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Detalhes bibliográficos
Main Authors: Sotomayor, Marcos, Weihofen, Wilhelm A., Gaudet, Rachelle, Corey, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518760/
https://ncbi.nlm.nih.gov/pubmed/23135401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11590
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