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Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity

Protease-activated receptor-1 (PAR1) is an unusual G-protein coupled receptor (GPCR) that is activated through proteolytic cleavage by extracellular serine proteases. While previous work has shown that inhibiting PAR1 activation is neuroprotective in models of ischemia, traumatic injury, and neuroto...

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Autori principali: Almonte, Antoine G., Qadri, Laura H., Sultan, Faraz A., Watson, Jennifer A., Mount, Daniel J., Rumbaugh, Gavin, Sweatt, J. David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518655/
https://ncbi.nlm.nih.gov/pubmed/23113835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12075
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