A carregar...

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

Live, attenuated RNA virus vaccines are efficacious but subject to reversion to virulence. Among RNA viruses, replication fidelity is recognized as a key determinant of virulence and escape from antiviral therapy; increased fidelity is attenuating for some viruses. Coronavirus (CoV) replication fide...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Graham, Rachel L, Becker, Michelle M, Eckerle, Lance D, Bolles, Meagan, Denison, Mark R, Baric, Ralph S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518599/
https://ncbi.nlm.nih.gov/pubmed/23142821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2972
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!