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Ex vivo Enzymatic Treatment of Aged CD4 T Cells Restores Cognate T-cell Helper Function and Enhances Antibody Production in Mice
Previous in vitro studies have shown that CD4 T cells from old mice have defects in T cell receptor (TCR) signaling, immune synapse formation, activation, and proliferation. We have reported that removing a specific set of surface glycoproteins by ex vivo treatment with O-sialoglycoprotein endopepti...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518580/ https://ncbi.nlm.nih.gov/pubmed/23136198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200487 |
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