TLR2 ligation protects effector T cells from regulatory T-cell mediated suppression and repolarizes T helper responses following MVA-based cancer immunotherapy

Cancer immunotherapy is hampered by the immunosuppression maintained by regulatory T cells (Tregs) in tumor-bearing hosts. Stimulation of the Toll-like receptor 2 (TLR2) by Pam3Cys is known to affect Treg-mediated suppression. We found that Pam3Cys increases the proliferation of both CD4(+) effector...

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Hauptverfasser: Amiset, Laurent, Fend, Laetitia, Gatard-Scheikl, Tania, Rittner, Karola, Duong, Vanessa, Rooke, Ronald, Muller, Sylviane, Bonnefoy, Jean-Yves, Préville, Xavier, Haegel, Hélène
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2012
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518499/
https://ncbi.nlm.nih.gov/pubmed/23243590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21479
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