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The Art of “Cut and Run”: The Role of Rab14 GTPase in Regulating N-cadherin Shedding and Cell Motility
Rab14 and FAM116 define an endocytic recycling pathway that controls proteolytic N-cadherin cleavage by transporting ADAM10 protease to the plasma membrane. When this pathway is disrupted, diminished ADAM10-dependent N-cadherin shedding leads to increased cell-cell adhesion and inhibition of cell mo...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518450/ https://ncbi.nlm.nih.gov/pubmed/22595666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.05.002 |
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