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The Art of “Cut and Run”: The Role of Rab14 GTPase in Regulating N-cadherin Shedding and Cell Motility

Rab14 and FAM116 define an endocytic recycling pathway that controls proteolytic N-cadherin cleavage by transporting ADAM10 protease to the plasma membrane. When this pathway is disrupted, diminished ADAM10-dependent N-cadherin shedding leads to increased cell-cell adhesion and inhibition of cell mo...

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Hlavní autor: Prekeris, Rytis
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518450/
https://ncbi.nlm.nih.gov/pubmed/22595666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.05.002
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