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Programmable Multivalent Display of Receptor Ligands using Peptide Nucleic Acid Nanoscaffolds
Multivalent effects dictate the binding affinity of multiple ligands on one molecular entity to receptors. Integrins are receptors that mediate cell attachment through multivalent binding to peptide sequences within the extracellular matrix, and overexpression promotes the metastasis of some cancers...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518395/ https://ncbi.nlm.nih.gov/pubmed/22233624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1629 |
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