Steroid Biosynthesis and Renal Excretion in Human Essential Hypertension: Association With Blood Pressure and Endogenous Ouabain

BACKGROUND: Endogenous ouabain (EO) has been linked with long-term changes in sodium balance and cardiovascular structure and function. The biosynthesis of EO involves, cholesterol side-chain cleavage (CYP11A1), 3-β-hydroxysteroid dehydrogenase (HSD3B) with sequential metabolism of pregnenolone and...

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Hauptverfasser: Tripodi, Grazia, Citterio, Lorena, Kouznetsova, Tatiana, Lanzani, Chiara, Florio, Monica, Modica, Rossana, Messaggio, Elisabetta, Hamlyn, John M., Zagato, Laura, Bianchi, Giuseppe, Staessen, Jan A., Manunta, Paolo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518306/
https://ncbi.nlm.nih.gov/pubmed/19197249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ajh.2009.3
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