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Cytotoxic effects and specific gene expression alterations induced by I-125-labeled triplex-forming oligonucleotides
PURPOSE: Triplex-forming oligonucleotides (TFO) bind to the DNA double helix in a sequence-specific manner. Therefore, TFO seem to be a suitable carrier for Auger electron emitters to damage exclusively targeted DNA sequences, e.g., in tumor cells. We studied the influence of I-125 labeled TFO with...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Informa Healthcare
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518296/ https://ncbi.nlm.nih.gov/pubmed/22694342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/09553002.2012.702298 |
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