Gene targeted DNA double-strand break induction by (125)I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells.

A parallel binding motif 16mer triplex-forming oligonucleotide (TFO) complementary to a polypurine-polypyrimidine target region near the 3'-end of the SupF gene of plasmid pSP189 was labeled with [5-(125)I]dCMP at position 15. Following triplex formation and decay accumulation, radiation-induced sit...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Mezhevaya, K, Winters, T A, Neumann, R D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148705/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10518622/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.21.4282
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